Seroincidence of Human T-Lymphotropic Virus Type I Infection and Characterization of Seroconverters in Jamaican Food Handlers

In a prospective study of food handlers in Jamaica, we estimated the age- and sex-specific seroincidence of human T-lymphotropic virus type I (HTLV-I) infection. Of 682 sexually active adults (132 males and 550 females) who were initially seronegative, 12 (1 male and 11 females) seroconverted over 8...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2003-07, Vol.33 (3), p.387-392
Hauptverfasser: Van Veldhuisen, Paul C, Walters, Michael, Sawada, Takashi, Levine, Paul H, Wilks, Rainford, Hanchard, Barrie, Hisada, Michie
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Sprache:eng
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Zusammenfassung:In a prospective study of food handlers in Jamaica, we estimated the age- and sex-specific seroincidence of human T-lymphotropic virus type I (HTLV-I) infection. Of 682 sexually active adults (132 males and 550 females) who were initially seronegative, 12 (1 male and 11 females) seroconverted over 8 years of follow-up. The seroincidence was 1.2 per 1,000 person-years for males and 3.2 per 1,000 person-years for females. The age-standardized incidence was 1.8 times higher for females than for males (P = 0.55). Within a median of 4 years after seroconversion, the median HTLV-I provirus load was 500 copies/10 cells, and the median antibody titer was 1:3109. Four of 12 seroconverters developed antibody to the Tax regulatory protein. HTLV-I infection in this population occurred at a rate comparable with that described for a Japanese cohort. Provirus load, titer and appearance of antibody to the Tax regulatory protein were typical of chronic carriers within a few years of seroconversion.
ISSN:1525-4135
1944-7884
DOI:10.1097/00126334-200307010-00014