Translocations (17;20) in colorectal adenocarcinomas

Translocations (17;20) in colorectal adenocarcinomas

We describe new recurrent chromosome translocations (17;20) observed in 3 of 19 colorectal tumors. Two of them were identical: der(20)t(17;20)(q21;p12), resulting in the loss of 17(pter→q21) and the third was a dicentric dic(17;20)(p11;p12). A similar dicentric was described previously in one tumor...

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Veröffentlicht in:Cancer genetics and cytogenetics 1992-12, Vol.64 (2), p.183-185
Hauptverfasser: Fleischman, E.W., Konstantinova, L.N., Perevozchikov, A.G., Knisch, V.I.
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - genetics
Adult
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 20
Colorectal Neoplasms - genetics
Female
Humans
Karyotyping
Male
Middle Aged
Translocation, Genetic
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Zusammenfassung:We describe new recurrent chromosome translocations (17;20) observed in 3 of 19 colorectal tumors. Two of them were identical: der(20)t(17;20)(q21;p12), resulting in the loss of 17(pter→q21) and the third was a dicentric dic(17;20)(p11;p12). A similar dicentric was described previously in one tumor [1], but we report der(20)t(17;20)(q21;p12) for the first time.
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(92)90353-A