Terreulactones A, B, C, and D: Novel Acetylcholinesterase Inhibitors Produced by Aspergillus terreus: I. Taxonomy, Fermentation, Isolation and Biological Activities

In the course of screening for selective inhibitors of acetylcholinesterase from the microbial metabolites, four new meroterpenoid compounds, terreulactones A, B, C and D were isolated from solid state fermentation of Aspergillus terreus Fb000501. They showed potent inhibitory activities against ace...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2003/04/25, Vol.56(4), pp.344-350
Hauptverfasser:	CHO, KYUNG-MI, KIM, WON-GON, LEE, CHONG-KIL, YOO, ICK-DONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Aspergillus - chemistry Aspergillus - metabolism Aspergillus terreus Biological and medical sciences Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - metabolism Cholinesterase Inhibitors - pharmacology Fermentation Lactones - isolation & purification Lactones - metabolism Lactones - pharmacology Medical sciences Sesquiterpenes - isolation & purification Sesquiterpenes - metabolism Sesquiterpenes - pharmacology Soil Microbiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In the course of screening for selective inhibitors of acetylcholinesterase from the microbial metabolites, four new meroterpenoid compounds, terreulactones A, B, C and D were isolated from solid state fermentation of Aspergillus terreus Fb000501. They showed potent inhibitory activities against acetylcholinesterase with IC50 values in range of 0.06-0.42μM. In addition, they exhibited more than 500-3000 times selectivity for acetylcholinesterase compared with butyrylcholinesterase.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.56.344