The thromboxane receptors of rat and guinea-pig lung

The thromboxane (TXA 2) receptors on rat and guinea-pig lung strips were compared using TXA 2 agonists and TXA 2 receptor antagonists. On rat lung strip several TXA 2 mimetics were full agonists whilst the primary prostanoids lacked agonist activity. On guinea-pig lung strip the same agonists displa...

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Veröffentlicht in:	European journal of pharmacology 1992-12, Vol.229 (2), p.171-178
Hauptverfasser:	Norman, Peter, Cuthbert, Nigel J., McKenniff, Marie G., Gardiner, Phillip J.
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 1S-(1α,2α(Z),3β(1(E),3S),4α)-7-(3-(3-hydroxy-4-(4-iodophenoxy)-1-butenyl)-7-oxabicyclo(2,2,1)hept-2-yl-5-heptenoic acid) Air breathing Animals antagonists BAY u3405 Biological and medical sciences Bridged Bicyclo Compounds - metabolism Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic Carbazoles - metabolism Carbazoles - pharmacology Dose-Response Relationship, Drug Fatty Acids, Unsaturated - metabolism Fatty Acids, Unsaturated - pharmacology Fundamental and applied biological sciences. Psychology Guinea Pigs I-BOP In Vitro Techniques lung Lung - chemistry Lung - drug effects Lung - physiology Lung strip Male Muscle Contraction - drug effects Muscle, Smooth - chemistry Muscle, Smooth - drug effects Muscle, Smooth - physiology Prostaglandin Endoperoxides, Synthetic - metabolism Prostaglandin Endoperoxides, Synthetic - pharmacology Rats Rats, Sprague-Dawley receptors Receptors, Thromboxane - antagonists & inhibitors Receptors, Thromboxane - drug effects Receptors, Thromboxane - metabolism Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Sulfonamides - metabolism Sulfonamides - pharmacology thromboxane A2 Thromboxane receptor antagonists Thromboxane receptors Thromboxanes - antagonists & inhibitors U46619 Vertebrates: respiratory system
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Beschreibung
Zusammenfassung:	The thromboxane (TXA 2) receptors on rat and guinea-pig lung strips were compared using TXA 2 agonists and TXA 2 receptor antagonists. On rat lung strip several TXA 2 mimetics were full agonists whilst the primary prostanoids lacked agonist activity. On guinea-pig lung strip the same agonists displayed markedly different efficacies. Both preparations contained homogenous populations of TXA 2 receptors as evidenced by BAY u3405 giving comparable pA 2 values against four TXA 2 mimetics. However, the observed pA 2's of nine different TXA 2 receptor antagonists, determined against U46619, did not correlate between the two preparations. These results point to the existence of TXA 2 receptor subtypes.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(92)90552-F