Reduced effects of endothelium-derived hyperpolarizing factor in ocular ciliary arteries from spontaneous hypertensive rats

Vascular peripheral resistance is increased during hypertension, and endothelium-derived hyperpolarizing factor (EDHF) is an important for regulating vasodilation in small arteries. Therefore we characterized the role of EDHF in regulating vascular resistance of ocular ciliary arteries from spontane...

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Veröffentlicht in:	Experimental eye research 2010-02, Vol.90 (2), p.324-329
Hauptverfasser:	Dong, Yaru, Watabe, Hiroshi, Cui, Jizhe, Abe, Sanae, Sato, Noriko, Ishikawa, Hitoshi, Yoshitomi, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Biological Factors - physiology BK Ca channel Blood Pressure Ciliary Arteries - physiology Dose-Response Relationship, Drug Endothelium, Vascular - physiology endothelium-derived hyperpolarizing factor Heart Rate hypertension Hypertension - physiopathology Isometric Contraction - drug effects Male Muscle, Smooth, Vascular - physiology Norepinephrine - pharmacology ocular ciliary artery Potassium Channels, Calcium-Activated - metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Vascular Resistance - physiology Vasodilation - physiology
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Zusammenfassung:	Vascular peripheral resistance is increased during hypertension, and endothelium-derived hyperpolarizing factor (EDHF) is an important for regulating vasodilation in small arteries. Therefore we characterized the role of EDHF in regulating vascular resistance of ocular ciliary arteries from spontaneous hypertensive rats (SHR) and age-matched Wistar Kyoto rats (WKY). Isometric tension recordings were used in isolated ocular ciliary artery segments from SHR and WKY. Ocular ciliary arteries pre-contracted with 100 μM norepinephrine exhibited a concentration-dependent relaxation to acetylcholine, and the effect on SHR arteries was smaller than that on WKY arteries ( P
ISSN:	0014-4835 1096-0007
DOI:	10.1016/j.exer.2009.11.009