Analysis of a framework using material balances in metabolic pathways to elucidate cellular metabolism

A framework using material balances in metabolic pathways to study cellular metabolism is examined and the results are discussed. Rate measurements on extracellular compounds alone were found to be not always sufficient to validate proposed unique intracellular mechanisms. The conditions to delineat...

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Veröffentlicht in:	Biotechnology and bioengineering 1989-08, Vol.34 (4), p.496-501
Hauptverfasser:	Niranjan, S. C., San, Ka-Yiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biology of microorganisms of confirmed or potential industrial interest Biotechnology Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Mission oriented research Physiology and metabolism
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Zusammenfassung:	A framework using material balances in metabolic pathways to study cellular metabolism is examined and the results are discussed. Rate measurements on extracellular compounds alone were found to be not always sufficient to validate proposed unique intracellular mechanisms. The conditions to delineate among candidate mechanisms based solely on extracellular measurements are established. The number of half reactions comprising the reaction network is found to be an important parameter.
ISSN:	0006-3592 1097-0290
DOI:	10.1002/bit.260340409