The molecular biology of the porcine paramyxovirus LPMV
Protein and genomic studies of a previously uncharacterized porcine paramyxovirus (designated LPMV) confirmed that it was a member of the paramyxovirus genus. The nucleotide sequences and deduced amino acids of the complete P-gene, M-gene, F-gene and HN-gene as well as the intergenic sequences have...
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Veröffentlicht in: | Veterinary microbiology 1992-11, Vol.33 (1), p.263-273 |
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creator | Linné, Tommy Berg, Mikael Bergvall, Ann-Christin Hjertner, Bernt Moreno-López, Jorge |
description | Protein and genomic studies of a previously uncharacterized porcine paramyxovirus (designated LPMV) confirmed that it was a member of the paramyxovirus genus. The nucleotide sequences and deduced amino acids of the complete P-gene, M-gene, F-gene and HN-gene as well as the intergenic sequences have been determined. Comparative sequence analysis of the M-gene of LPMV revealed the closest relationship of LPMV was to human mumps virus with a homology of 46% and 55% at the amino acid and nucleotide levels respectively. The P-gene of LPMV is transcribed to V protein mRNA and by editing of the gene to the P protein mRNA. The LPMV P-gene has the coding capacity for an additional protein of 126 amino acids, a C protein. |
doi_str_mv | 10.1016/0378-1135(92)90054-W |
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The nucleotide sequences and deduced amino acids of the complete P-gene, M-gene, F-gene and HN-gene as well as the intergenic sequences have been determined. Comparative sequence analysis of the M-gene of LPMV revealed the closest relationship of LPMV was to human mumps virus with a homology of 46% and 55% at the amino acid and nucleotide levels respectively. The P-gene of LPMV is transcribed to V protein mRNA and by editing of the gene to the P protein mRNA. The LPMV P-gene has the coding capacity for an additional protein of 126 amino acids, a C protein.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>CERDO</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>GENE</topic><topic>GENES</topic><topic>Genetics</topic><topic>Genome, Viral</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>NUCLEOTIDE SEQUENCE</topic><topic>PARAMYXOVIRIDAE</topic><topic>Paramyxoviridae - classification</topic><topic>Paramyxoviridae - genetics</topic><topic>Paramyxoviridae - ultrastructure</topic><topic>PORCIN</topic><topic>Respirovirus Infections - microbiology</topic><topic>Respirovirus Infections - veterinary</topic><topic>RNA, Viral - chemistry</topic><topic>SECUENCIA NUCLEICA</topic><topic>SEQUENCE NUCLEIQUE</topic><topic>SWINE</topic><topic>Swine Diseases - microbiology</topic><topic>Viral Proteins - chemistry</topic><topic>Viral Proteins - genetics</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linné, Tommy</creatorcontrib><creatorcontrib>Berg, Mikael</creatorcontrib><creatorcontrib>Bergvall, Ann-Christin</creatorcontrib><creatorcontrib>Hjertner, Bernt</creatorcontrib><creatorcontrib>Moreno-López, Jorge</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linné, Tommy</au><au>Berg, Mikael</au><au>Bergvall, Ann-Christin</au><au>Hjertner, Bernt</au><au>Moreno-López, Jorge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The molecular biology of the porcine paramyxovirus LPMV</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>33</volume><issue>1</issue><spage>263</spage><epage>273</epage><pages>263-273</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>Protein and genomic studies of a previously uncharacterized porcine paramyxovirus (designated LPMV) confirmed that it was a member of the paramyxovirus genus. The nucleotide sequences and deduced amino acids of the complete P-gene, M-gene, F-gene and HN-gene as well as the intergenic sequences have been determined. Comparative sequence analysis of the M-gene of LPMV revealed the closest relationship of LPMV was to human mumps virus with a homology of 46% and 55% at the amino acid and nucleotide levels respectively. The P-gene of LPMV is transcribed to V protein mRNA and by editing of the gene to the P protein mRNA. The LPMV P-gene has the coding capacity for an additional protein of 126 amino acids, a C protein.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1481359</pmid><doi>10.1016/0378-1135(92)90054-W</doi><tpages>11</tpages></addata></record> |
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subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences CERDO Fundamental and applied biological sciences. Psychology GENE GENES Genetics Genome, Viral Microbiology Molecular Sequence Data NUCLEOTIDE SEQUENCE PARAMYXOVIRIDAE Paramyxoviridae - classification Paramyxoviridae - genetics Paramyxoviridae - ultrastructure PORCIN Respirovirus Infections - microbiology Respirovirus Infections - veterinary RNA, Viral - chemistry SECUENCIA NUCLEICA SEQUENCE NUCLEIQUE SWINE Swine Diseases - microbiology Viral Proteins - chemistry Viral Proteins - genetics Virology |
title | The molecular biology of the porcine paramyxovirus LPMV |
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