The molecular biology of the porcine paramyxovirus LPMV

Protein and genomic studies of a previously uncharacterized porcine paramyxovirus (designated LPMV) confirmed that it was a member of the paramyxovirus genus. The nucleotide sequences and deduced amino acids of the complete P-gene, M-gene, F-gene and HN-gene as well as the intergenic sequences have...

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Veröffentlicht in:	Veterinary microbiology 1992-11, Vol.33 (1), p.263-273
Hauptverfasser:	Linné, Tommy, Berg, Mikael, Bergvall, Ann-Christin, Hjertner, Bernt, Moreno-López, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences CERDO Fundamental and applied biological sciences. Psychology GENE GENES Genetics Genome, Viral Microbiology Molecular Sequence Data NUCLEOTIDE SEQUENCE PARAMYXOVIRIDAE Paramyxoviridae - classification Paramyxoviridae - genetics Paramyxoviridae - ultrastructure PORCIN Respirovirus Infections - microbiology Respirovirus Infections - veterinary RNA, Viral - chemistry SECUENCIA NUCLEICA SEQUENCE NUCLEIQUE SWINE Swine Diseases - microbiology Viral Proteins - chemistry Viral Proteins - genetics Virology
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Zusammenfassung:	Protein and genomic studies of a previously uncharacterized porcine paramyxovirus (designated LPMV) confirmed that it was a member of the paramyxovirus genus. The nucleotide sequences and deduced amino acids of the complete P-gene, M-gene, F-gene and HN-gene as well as the intergenic sequences have been determined. Comparative sequence analysis of the M-gene of LPMV revealed the closest relationship of LPMV was to human mumps virus with a homology of 46% and 55% at the amino acid and nucleotide levels respectively. The P-gene of LPMV is transcribed to V protein mRNA and by editing of the gene to the P protein mRNA. The LPMV P-gene has the coding capacity for an additional protein of 126 amino acids, a C protein.
ISSN:	0378-1135 1873-2542
DOI:	10.1016/0378-1135(92)90054-W