A Systematic Review of Implementation of Established Recommended Secondary Prevention Measures in Patients with PAOD

Abstract Objective Since patients with peripheral arterial occlusive disease (PAOD) are at high-risk for cardiovascular morbidity and mortality, preventive measures aimed to reduce cardiovascular adverse events are advocated in the current guidelines. We conducted a systematic review to assess the i...

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Veröffentlicht in:European journal of vascular and endovascular surgery 2010-01, Vol.39 (1), p.70-86
Hauptverfasser: Flu, H.C, Tamsma, J.T, Lindeman, J.H.N, Hamming, J.F, Lardenoye, J.H.P
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Sprache:eng
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Zusammenfassung:Abstract Objective Since patients with peripheral arterial occlusive disease (PAOD) are at high-risk for cardiovascular morbidity and mortality, preventive measures aimed to reduce cardiovascular adverse events are advocated in the current guidelines. We conducted a systematic review to assess the implementation of secondary prevention (SP) measures in PAOD patients. Methods PubMed, Cochrane Library, EMBASE and Web of Science databases were searched to perform a systematic review of the literature from 1999 till June 2008 on SP for PAOD patients. Assessment of study quality was done following the Cochrane Library review system. The record outcomes were antiplatelet agents, heart rate lowering agents, blood pressure lowering agents, lipid lowering agents, glucose lowering agents, smoking cessation and walking exercise. Results From a total of 2137 identified studies, 83 observational studies met the inclusion criteria, of which 24 were included in the systematic review comprising 34 157 patients. These patients suffered from coronary artery disease ( n = 3516, 41%), myocardial infraction ( n = 2647, 38%), angina pectoris ( n = 1790, 31%), congestive heart failure ( n = 2052, 14%), diabetes mellitus ( n = 10 690, 31%),hypertension ( n = 20 823, 73%) and hyperlipidaemia ( n = 15 067, 64%). Contrary to what the guidelines prescribe, antiplatelet agents, heart rate lowering agents, blood pressure lowering agents and lipid lowering agents were prescribed in 63%, 34%, 46% and 45% of the patients, respectively. Glucose lowering agents were prescribed in 81% and smoking cessation in 39% of the patients. Conclusion The majority of patients suffering from PAOD do not receive the entire approach of SP measures as suggested by the current guidelines. To our knowledge, the cause of this undertreatment is multifactorial: patient, physician or health-care-related.
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2009.09.027