Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor
The synthesis of ligand 4 binds to G-CSF receptor is reported. Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010-02, Vol.20 (3), p.1169-1172 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The synthesis of ligand
4 binds to G-CSF receptor is reported.
Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2009.12.010 |