Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor

The synthesis of ligand 4 binds to G-CSF receptor is reported. Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2010-02, Vol.20 (3), p.1169-1172
Hauptverfasser: El-Haggar, Radwan, Kamikawa, Ken, Machi, Kazuya, Ye, Zhengmao, Ishino, Yuko, Tsumuraya, Takeshi, Fujii, Ikuo
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Sprache:eng
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Zusammenfassung:The synthesis of ligand 4 binds to G-CSF receptor is reported. Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2009.12.010