Influence of amorolfine on the morphology of Candida albicans and Trichophyton mentagrophytes

Summary Amorolfine applied in concentrations of 0·1‐100 μg/ml causes considerable damage to the ultrastructure of Candida albicans and Trichophyton mentagrophytes: electron‐lucent areas appear in the cytoplasm; extracytoplasmic membrane vesicles are formed and deposited in the cell wall; starved fungal cells, with normal ultrastructure, can be found; lysed, dead cells demonstrate the process of severe ultrastructural damage; T. mentagrophytes cell walls especially increase in thickness. The extent of the damage caused by amorolfine is comparable to that produced by azole antifungals.