A cost-effectiveness comparison of embryo donation with oocyte donation

Objective To compare the cost-effectiveness of embryo donation (ED) to that of oocyte donation (OD). Design Calculation of cost-effectiveness ratios (costs per outcome achieved) using data derived from clinical practices. Setting In vitro fertilization centers and embryo donation programs. Patient(s) Infertile couples undergoing oocyte donation or embryo donation. Intervention(s) Oocyte donation or embryo donation cycles. Main Outcome Measure(s) Cost-effectiveness ratios. Result(s) For a single cycle, ED is approximately twice as cost-effective as OD, with a cost-effectiveness ratio of $21,990 per live delivery compared to $40,600. When strategies of up to three cycles (to achieve one live delivery) are used, ED costs $13,505 per live delivery compared to $31,349 for OD. Conclusion(s) Cost-effectiveness is a compelling reason for infertile couples to consider embryo donation.