Binding of d-mannose to poly(2-hydroxyethyl methacrylate) hydrogels by azo coupling

Binding of d-mannose to poly(2-hydroxyethyl methacrylate) hydrogels by azo coupling

Crosslinked hydrogels based on poly(2-hydroxyethyl methacrylate) poly(HEMA) were prepared and modified with tyramine [4-(2-aminoethyl)phenol] to enable azo coupling with mannosyl derivatives, copolymerization of HEMA with polymerizable activated esters and surface modification reaction with 4-nitrop...

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Veröffentlicht in:Biomaterials 2003-10, Vol.24 (22), p.4031-4036
1. Verfasser: Labský, Jiřı́
Format: Artikel
Sprache:eng
Schlagworte:
4-(Mannopyranosyloxy)benzene-1-diazonium chloride
Activated esters
Azo compounds
Biocompatible Materials
Esters
Formates - chemistry
Hydrogels
Hydrogels - chemistry
Keratinocytes - metabolism
Mannose
Mannose - chemistry
Mannose-rich hydrogels
Models, Chemical
Nitrophenols - chemistry
Polyhydroxyethyl Methacrylate - analogs & derivatives
Polyhydroxyethyl Methacrylate - chemistry
Polymers
Spacer
Tyramine - chemistry
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Zusammenfassung:Crosslinked hydrogels based on poly(2-hydroxyethyl methacrylate) poly(HEMA) were prepared and modified with tyramine [4-(2-aminoethyl)phenol] to enable azo coupling with mannosyl derivatives, copolymerization of HEMA with polymerizable activated esters and surface modification reaction with 4-nitrophenyl chlorocarbonate for activation of the hydrogels were used.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(03)00313-2