Two unusual acetogenins from the roots of Annona salzmanii

Two new acetogenins, parisin (1) and salzmanolin (2), were isolated from a MeOH extract of the roots of Annona salzmanii. The structures of 1 and 2 were elucidated by spectroscopic methods including LSI-MS/MS, on both the natural compounds and their acetonide derivatives (1a and 2a). Compounds 1 and...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-06, Vol.66 (6), p.755-758
Hauptverfasser:	Queiroz, E.F, Roblot, F, Laprevote, O, Paulo, M. de Q, Hocquemiller, R
Format:	Artikel
Sprache:	eng
Schlagworte:	acetogenins acetonide Animals Annona Annona - chemistry Annona salzmanii Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Brazil carbon cell lines Cercopithecus aethiops chemical structure cytotoxicity Drug Screening Assays, Antitumor furans Furans - chemistry Furans - isolation & purification Furans - pharmacology General pharmacology Humans KB Cells - drug effects lactones Medical sciences Molecular Structure oxymethine proton parisin Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plant Roots - chemistry Plants, Medicinal - chemistry protons roots salzmanolin spectral analysis stereochemistry Tumor Cells, Cultured - drug effects Vero Cells
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Zusammenfassung:	Two new acetogenins, parisin (1) and salzmanolin (2), were isolated from a MeOH extract of the roots of Annona salzmanii. The structures of 1 and 2 were elucidated by spectroscopic methods including LSI-MS/MS, on both the natural compounds and their acetonide derivatives (1a and 2a). Compounds 1 and 2 showed significant activity against the KB and Vero cell lines.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np020543h