Efficacy and safety of aliskiren in Japanese hypertensive patients with renal dysfunction

This 12-week, multicenter, open-label study assessed the efficacy, pharmacokinetics and safety of a once-daily aliskiren in Japanese hypertensive patients with renal dysfunction. Patients ( n =40, aged 20–80 years) with mean sitting diastolic blood pressure (msDBP) ⩾95 and

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Bibliographische Detailangaben
Veröffentlicht in:	Hypertension research 2010-01, Vol.33 (1), p.62-66
Hauptverfasser:	Ito, Sadayoshi, Nakura, Noriko, Le Breton, Stephanie, Keefe, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amides - adverse effects Amides - pharmacokinetics Amides - therapeutic use Antihypertensive Agents - adverse effects Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - therapeutic use Blood Chemical Analysis Dose-Response Relationship, Drug Double-Blind Method Female Fumarates - adverse effects Fumarates - pharmacokinetics Fumarates - therapeutic use Geriatrics/Gerontology Health Promotion and Disease Prevention Humans Hypertension - complications Hypertension - drug therapy Hypertension - physiopathology Internal Medicine Japan Kidney Diseases - complications Male Medicine Medicine & Public Health Middle Aged Obstetrics/Perinatology/Midwifery original-article Public Health Renin - antagonists & inhibitors Renin-Angiotensin System - drug effects Risk Assessment Young Adult
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Beschreibung
Zusammenfassung:	This 12-week, multicenter, open-label study assessed the efficacy, pharmacokinetics and safety of a once-daily aliskiren in Japanese hypertensive patients with renal dysfunction. Patients ( n =40, aged 20–80 years) with mean sitting diastolic blood pressure (msDBP) ⩾95 and
ISSN:	0916-9636 1348-4214
DOI:	10.1038/hr.2009.175