Soluble HLA-G1 at the Materno-foetal Interface—A Review

HLA-G differs from the other MHC class I genes. This includes a unique promoter region, a restricted constitutive tissular distribution, the translation of different membrane-bound and soluble isoforms, a shortened cytoplasmic tail and a minimal polymorphim. Soluble HLA-G1 is an immunosuppressive mo...

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Veröffentlicht in:	Placenta (Eastbourne) 2003-04, Vol.24, p.S10-S15
Hauptverfasser:	Le Bouteiller, P, Legrand-Abravanel, F, Solier, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - immunology Biological and medical sciences CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Embryo Implantation - immunology Embryology: invertebrates and vertebrates. Teratology Endothelium, Vascular - immunology Female Fundamental and applied biological sciences. Psychology Genes, MHC Class I Histocompatibility Antigens Class I - chemistry Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism HLA Antigens - chemistry HLA Antigens - genetics HLA Antigens - metabolism HLA-G Antigens Humans Maternal-Fetal Exchange - immunology Models, Immunological Placenta - immunology Pregnancy Promoter Regions, Genetic Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Solubility
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Beschreibung
Zusammenfassung:	HLA-G differs from the other MHC class I genes. This includes a unique promoter region, a restricted constitutive tissular distribution, the translation of different membrane-bound and soluble isoforms, a shortened cytoplasmic tail and a minimal polymorphim. Soluble HLA-G1 is an immunosuppressive molecule inducing apoptosis of activated CD8+ T cells and down-modulating CD4+ T cell proliferation. Soluble HLA-G1 may also contribute to the control of implantation.
ISSN:	0143-4004 1532-3102
DOI:	10.1053/plac.2002.0931