Enhanced Immunogenicity of Seasonal Influenza Vaccines in Young Children Using MF59 Adjuvant

BACKGROUND:Children have high morbidity and hospitalization rates from seasonal influenza. Meta-analyses suggest that conventional inactivated influenza vaccines are of low efficacy in young children, making vaccines that induce greater and broader immune protection in this vulnerable population a m...

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Veröffentlicht in:	The Pediatric infectious disease journal 2009-07, Vol.28 (7), p.563-571
Hauptverfasser:	Vesikari, Timo, Pellegrini, Michele, Karvonen, Aino, Groth, Nicola, Borkowski, Astrid, OʼHagan, Derek T, Podda, Audino
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - adverse effects Antibodies, Viral - blood Biological and medical sciences Child, Preschool Hemagglutination Inhibition Tests Human viral diseases Humans Immunization, Secondary - methods Infant Infectious diseases Influenza A virus - immunology Influenza B virus - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Influenza, Human - prevention & control Male Medical sciences Polysorbates - administration & dosage Polysorbates - adverse effects Squalene - administration & dosage Squalene - adverse effects Vaccination - methods Viral diseases Viral diseases of the respiratory system and ent viral diseases
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Zusammenfassung:	BACKGROUND:Children have high morbidity and hospitalization rates from seasonal influenza. Meta-analyses suggest that conventional inactivated influenza vaccines are of low efficacy in young children, making vaccines that induce greater and broader immune protection in this vulnerable population a medical priority. Adjuvanted influenza vaccines may offer a solution. SUBJECTS AND METHODS:Unprimed healthy children (6 to
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e31819d6394