Synthesis of fluorinated allenes via palladium-catalyzed monofluoromethylation using FBSM

Synthesis of fluorinated allenes via palladium-catalyzed monofluoromethylation using FBSM

Palladium-catalyzed monofluoromethylation of substituted 2-bromo-1,3-dienes using fluorobis(phenylsulfonyl)methane (FBSM) as a pronucleophile gave previously unknown monofluoromethylated allenes in high yields, which are the isosteres of biologically attractive allenic alcohols.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (47), p.7366-7368
Hauptverfasser: Ogasawara, Masamichi, Murakami, Hidetoshi, Furukawa, Tatsuya, Takahashi, Tamotsu, Shibata, Norio
Format: Artikel
Sprache:eng
Schlagworte:
Alkadienes - chemical synthesis
Bromine Compounds - chemistry
Catalysis
Fluorine - chemistry
Hydrocarbons, Fluorinated - chemistry
Methane - analogs & derivatives
Methane - chemistry
Methylation
Molecular Structure
Palladium - chemistry
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Zusammenfassung:Palladium-catalyzed monofluoromethylation of substituted 2-bromo-1,3-dienes using fluorobis(phenylsulfonyl)methane (FBSM) as a pronucleophile gave previously unknown monofluoromethylated allenes in high yields, which are the isosteres of biologically attractive allenic alcohols.
ISSN:1359-7345
1364-548X
DOI:10.1039/b912531k