Myc and a Cdk2 senescence switch
Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.
Gespeichert in:
| Veröffentlicht in: | Nature cell biology 2010-01, Vol.12 (1), p.7-9 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9 |
|---|---|
| container_issue | 1 |
| container_start_page | 7 |
| container_title | Nature cell biology |
| container_volume | 12 |
| creator | van Riggelen, Jan Felsher, Dean W |
| description | Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer. |
| doi_str_mv | 10.1038/ncb0110-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734203597</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1926111501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-9e701110612e17cbdaca1d4f6e84f107bf1ced3b18b09f4fbba6677ed249d5583</originalsourceid><addsrcrecordid>eNptkVtLw0AQhRdRbK0--Ac0-CIK0dlLst1HKd6g4os-h71MtLXd1N0E6b83IbWCOC8zMB9nDmcIOaZwRYGPr701QCmkcocMqZB5KnKpdrs5z1LJFRuQgxjnAFQIkPtkwACYpEoNSfK0ton2LtHJxH2wJKLHaNFbTOLXrLbvh2Sv1IuIR5s-Iq93ty-Th3T6fP84uZmmlkuoU4WytUAhpwyptMZpq6kTZY5jUVKQpqQWHTd0bECVojRG57mU6JhQLsvGfETOe91VqD4bjHWxnLVGFgvtsWpiIblgwDMlW_LsDzmvmuBbcwVrS4KkHXTRQzZUMQYsi1WYLXVYFxSKLrRiE1rRsScbwcYs0W3Jn5Ra4LIHYrvybxh-L_6ndtrDXtdNwK3a9kn8G6SbfOY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222270717</pqid></control><display><type>article</type><title>Myc and a Cdk2 senescence switch</title><source>MEDLINE</source><source>Nature Journals Online</source><source>Alma/SFX Local Collection</source><creator>van Riggelen, Jan ; Felsher, Dean W</creator><creatorcontrib>van Riggelen, Jan ; Felsher, Dean W</creatorcontrib><description>Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.</description><identifier>ISSN: 1465-7392</identifier><identifier>EISSN: 1476-4679</identifier><identifier>DOI: 10.1038/ncb0110-7</identifier><identifier>PMID: 20027199</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/80/509 ; 692/420/755 ; Animals ; Biomedical and Life Sciences ; Cancer Research ; Cell Biology ; Cellular Senescence - physiology ; Cyclin-Dependent Kinase 2 - physiology ; Developmental Biology ; Genes, myc - physiology ; Humans ; Life Sciences ; Neoplasms - metabolism ; Neoplasms - pathology ; news-and-views ; Stem Cells</subject><ispartof>Nature cell biology, 2010-01, Vol.12 (1), p.7-9</ispartof><rights>Springer Nature Limited 2010</rights><rights>Copyright Nature Publishing Group Jan 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-9e701110612e17cbdaca1d4f6e84f107bf1ced3b18b09f4fbba6677ed249d5583</citedby><cites>FETCH-LOGICAL-c370t-9e701110612e17cbdaca1d4f6e84f107bf1ced3b18b09f4fbba6677ed249d5583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2729,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20027199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Riggelen, Jan</creatorcontrib><creatorcontrib>Felsher, Dean W</creatorcontrib><title>Myc and a Cdk2 senescence switch</title><title>Nature cell biology</title><addtitle>Nat Cell Biol</addtitle><addtitle>Nat Cell Biol</addtitle><description>Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.</description><subject>631/80/509</subject><subject>692/420/755</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cellular Senescence - physiology</subject><subject>Cyclin-Dependent Kinase 2 - physiology</subject><subject>Developmental Biology</subject><subject>Genes, myc - physiology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>news-and-views</subject><subject>Stem Cells</subject><issn>1465-7392</issn><issn>1476-4679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkVtLw0AQhRdRbK0--Ac0-CIK0dlLst1HKd6g4os-h71MtLXd1N0E6b83IbWCOC8zMB9nDmcIOaZwRYGPr701QCmkcocMqZB5KnKpdrs5z1LJFRuQgxjnAFQIkPtkwACYpEoNSfK0ton2LtHJxH2wJKLHaNFbTOLXrLbvh2Sv1IuIR5s-Iq93ty-Th3T6fP84uZmmlkuoU4WytUAhpwyptMZpq6kTZY5jUVKQpqQWHTd0bECVojRG57mU6JhQLsvGfETOe91VqD4bjHWxnLVGFgvtsWpiIblgwDMlW_LsDzmvmuBbcwVrS4KkHXTRQzZUMQYsi1WYLXVYFxSKLrRiE1rRsScbwcYs0W3Jn5Ra4LIHYrvybxh-L_6ndtrDXtdNwK3a9kn8G6SbfOY</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>van Riggelen, Jan</creator><creator>Felsher, Dean W</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201001</creationdate><title>Myc and a Cdk2 senescence switch</title><author>van Riggelen, Jan ; Felsher, Dean W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-9e701110612e17cbdaca1d4f6e84f107bf1ced3b18b09f4fbba6677ed249d5583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/80/509</topic><topic>692/420/755</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer Research</topic><topic>Cell Biology</topic><topic>Cellular Senescence - physiology</topic><topic>Cyclin-Dependent Kinase 2 - physiology</topic><topic>Developmental Biology</topic><topic>Genes, myc - physiology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>news-and-views</topic><topic>Stem Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Riggelen, Jan</creatorcontrib><creatorcontrib>Felsher, Dean W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Riggelen, Jan</au><au>Felsher, Dean W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myc and a Cdk2 senescence switch</atitle><jtitle>Nature cell biology</jtitle><stitle>Nat Cell Biol</stitle><addtitle>Nat Cell Biol</addtitle><date>2010-01</date><risdate>2010</risdate><volume>12</volume><issue>1</issue><spage>7</spage><epage>9</epage><pages>7-9</pages><issn>1465-7392</issn><eissn>1476-4679</eissn><abstract>Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20027199</pmid><doi>10.1038/ncb0110-7</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1465-7392 |
| ispartof | Nature cell biology, 2010-01, Vol.12 (1), p.7-9 |
| issn | 1465-7392 1476-4679 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734203597 |
| source | MEDLINE; Nature Journals Online; Alma/SFX Local Collection |
| subjects | 631/80/509 692/420/755 Animals Biomedical and Life Sciences Cancer Research Cell Biology Cellular Senescence - physiology Cyclin-Dependent Kinase 2 - physiology Developmental Biology Genes, myc - physiology Humans Life Sciences Neoplasms - metabolism Neoplasms - pathology news-and-views Stem Cells |
| title | Myc and a Cdk2 senescence switch |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T01%3A23%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Myc%20and%20a%20Cdk2%20senescence%20switch&rft.jtitle=Nature%20cell%20biology&rft.au=van%20Riggelen,%20Jan&rft.date=2010-01&rft.volume=12&rft.issue=1&rft.spage=7&rft.epage=9&rft.pages=7-9&rft.issn=1465-7392&rft.eissn=1476-4679&rft_id=info:doi/10.1038/ncb0110-7&rft_dat=%3Cproquest_cross%3E1926111501%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222270717&rft_id=info:pmid/20027199&rfr_iscdi=true |