Myc and a Cdk2 senescence switch

Myc and a Cdk2 senescence switch

Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

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Bibliographische Detailangaben
Veröffentlicht in:Nature cell biology 2010-01, Vol.12 (1), p.7-9
Hauptverfasser: van Riggelen, Jan, Felsher, Dean W
Format: Artikel
Sprache:eng
Schlagworte:
631/80/509
692/420/755
Animals
Biomedical and Life Sciences
Cancer Research
Cell Biology
Cellular Senescence - physiology
Cyclin-Dependent Kinase 2 - physiology
Developmental Biology
Genes, myc - physiology
Humans
Life Sciences
Neoplasms - metabolism
Neoplasms - pathology
news-and-views
Stem Cells
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Beschreibung
Zusammenfassung:Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.
ISSN:1465-7392
1476-4679
DOI:10.1038/ncb0110-7