Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands

An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 microM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear rut...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2009-01 (48), p.10712-10716
Hauptverfasser:	Sun, Raymond Wai-Yin, Ng, Miro Fei-Yeung, Wong, Ella Lai-Ming, Zhang, Jingfei, Chui, Stephen Sin-Yin, Shek, Lam, Lau, Tai-Chu, Che, Chi-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Apoptosis Ascorbic Acid - chemistry Cell Line, Tumor Coordination Complexes - chemistry Coordination Complexes - toxicity Crystallography, X-Ray Drug Screening Assays, Antitumor HeLa Cells Humans Ligands Molecular Conformation Pyrazoles - chemistry Ruthenium - chemistry
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Zusammenfassung:	An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 microM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)(4)X(2)](+) exhibit dual anti-angiogenic and cytotoxic properties.
ISSN:	1477-9226 1477-9234
DOI:	10.1039/b912236b