Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

Getting in there: Efficient intracellular delivery of anticancer drugs is achieved by using reversibly cross‐linked dextran nanoparticles, which are rapidly destabilized under reductive environments that mimic those of the intracellular compartments. These nanoparticles show high drug loading efficiency and reduction‐triggered release of doxorubicin in vitro as well as inside tumor cells, particularly to the cell nucleus (see scheme).