Alasmontamine A, A First Tetrakis Monoterpene Indole Alkaloid from Tabernaemontana elegans

A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2009-12, Vol.11 (24), p.5718-5721
Hauptverfasser:	Hirasawa, Yusuke, Miyama, Saori, Hosoya, Takahiro, Koyama, Koichiro, Rahman, Abdul, Kusumawati, Idha, Zaini, Noor Cholies, Morita, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Drug Screening Assays, Antitumor HL-60 Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Secologanin Tryptamine Alkaloids - chemistry Secologanin Tryptamine Alkaloids - isolation & purification Secologanin Tryptamine Alkaloids - pharmacology Tabernaemontana - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited moderate cell growth inhibitory activity against HL-60 cells.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol902420s