Chiral Phosphoric Acid Catalyzed Desymmetrization of meso-1,3-Diones: Asymmetric Synthesis of Chiral Cyclohexenones

Chiral Phosphoric Acid Catalyzed Desymmetrization of meso-1,3-Diones: Asymmetric Synthesis of Chiral Cyclohexenones

Chiral effectiveness: The title transformation is applicable to a wide variety of substrates to give chiral cyclohexenones in high yields and with excellent enantioselectivity (see scheme). To clarify the origin of the enantioselectivity ONIOM calculations were carried out

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (51), p.9652-9654
Hauptverfasser: Mori, Keiji, Katoh, Takuya, Suzuki, Tohru, Noji, Takuya, Yamanaka, Masahiro, Akiyama, Takahiko
Format: Artikel
Sprache:eng
Schlagworte:
aldol reaction
asymmetric synthesis
chiral phosphoric acids
computational chemistry
desymmetrization
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Beschreibung
Zusammenfassung:Chiral effectiveness: The title transformation is applicable to a wide variety of substrates to give chiral cyclohexenones in high yields and with excellent enantioselectivity (see scheme). To clarify the origin of the enantioselectivity ONIOM calculations were carried out
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200905271