Trypanocidal activity of extracts from Brazilian Atlantic Rain Forest plant species

The trypanocidal activity of crude hydro alcoholic extracts and several fractions of 13 plants from Brazilian Atlantic Rain Forest were tested in vitro against epimastigote and trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas disease. Crude ethanol extracts with promising i...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2003, Vol.10 (5), p.422-426
Hauptverfasser:	Pizzolatti, M.G., Koga, A.H., Grisard, E.C., Steindel, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atlantic Ocean Brazil Brazilian Atlantic Rain Forest plants Chagas' disease Chemical properties Drug therapy Health aspects Medicine, Traditional Physiological aspects Plant Components, Aerial - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Prevention Rain forest plants Tropical Climate Trypanocidal activity Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects
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Zusammenfassung:	The trypanocidal activity of crude hydro alcoholic extracts and several fractions of 13 plants from Brazilian Atlantic Rain Forest were tested in vitro against epimastigote and trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas disease. Crude ethanol extracts with promising in vitro activity (DL 50 between 5–10 μg/ml) against epimastigotes were fractionated by solvent partition and further tested against bloodstream form of the parasite. Activity against bloodstream parasites was observed in both dichloromethane and hexane fractions of Polygala sabulosa and P. paniculata.
ISSN:	0944-7113 1618-095X
DOI:	10.1078/0944-7113-00252