Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor
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| Veröffentlicht in: | Journal of medicinal chemistry 1992-12, Vol.35 (26), p.4914-4917 |
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| Hauptverfasser: | , , , , , |
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| container_end_page | 4917 |
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| container_issue | 26 |
| container_start_page | 4914 |
| container_title | Journal of medicinal chemistry |
| container_volume | 35 |
| creator | Zablocki, Jeffery A Miyano, Masateru Rao, Shashidhar N Panzer-Knodle, Susan Nicholson, Nancy Feigen, Larry |
| description | |
| doi_str_mv | 10.1021/jm00104a019 |
| format | Article |
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A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. 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A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor</title><author>Zablocki, Jeffery A ; Miyano, Masateru ; Rao, Shashidhar N ; Panzer-Knodle, Susan ; Nicholson, Nancy ; Feigen, Larry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a354t-2767d7c471411865b32f2b1313703b83e6a3f01f12ad22b4252df346f1b824513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>Fibrinogen - metabolism</topic><topic>Fibrinogen - pharmacology</topic><topic>Molecular Sequence Data</topic><topic>Oligopeptides - chemical synthesis</topic><topic>Oligopeptides - pharmacology</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - chemical synthesis</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet Glycoprotein GPIb-IX Complex</topic><topic>Platelet Membrane Glycoproteins</topic><topic>Receptors, Immunologic - drug effects</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zablocki, Jeffery A</creatorcontrib><creatorcontrib>Miyano, Masateru</creatorcontrib><creatorcontrib>Rao, Shashidhar N</creatorcontrib><creatorcontrib>Panzer-Knodle, Susan</creatorcontrib><creatorcontrib>Nicholson, Nancy</creatorcontrib><creatorcontrib>Feigen, Larry</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zablocki, Jeffery A</au><au>Miyano, Masateru</au><au>Rao, Shashidhar N</au><au>Panzer-Knodle, Susan</au><au>Nicholson, Nancy</au><au>Feigen, Larry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. 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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1992-12, Vol.35 (26), p.4914-4917 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73417827 |
| source | ACS Publications; MEDLINE |
| subjects | Amino Acid Sequence Fibrinogen - metabolism Fibrinogen - pharmacology Molecular Sequence Data Oligopeptides - chemical synthesis Oligopeptides - pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIb-IX Complex Platelet Membrane Glycoproteins Receptors, Immunologic - drug effects Receptors, Immunologic - metabolism Structure-Activity Relationship |
| title | Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor |
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