Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1992-12, Vol.35 (26), p.4914-4917
Hauptverfasser:	Zablocki, Jeffery A, Miyano, Masateru, Rao, Shashidhar N, Panzer-Knodle, Susan, Nicholson, Nancy, Feigen, Larry
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Fibrinogen - metabolism Fibrinogen - pharmacology Molecular Sequence Data Oligopeptides - chemical synthesis Oligopeptides - pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIb-IX Complex Platelet Membrane Glycoproteins Receptors, Immunologic - drug effects Receptors, Immunologic - metabolism Structure-Activity Relationship
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