A Preliminary Controlled Trial of Cognitive Behavioral Therapy in Clozapine-Resistant Schizophrenia

A Preliminary Controlled Trial of Cognitive Behavioral Therapy in Clozapine-Resistant Schizophrenia

The use of cognitive-behavior therapy (CBT) in addition to antipsychotic regimen to treat persistent psychotic symptoms of schizophrenia is growing. The aim of this study was to compare the efficacy of CBT to a befriending (BF) control group in patients with schizophrenia who are refractory to cloza...

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Veröffentlicht in:The journal of nervous and mental disease 2009-11, Vol.197 (11), p.865-868
Hauptverfasser: de Paiva Barretto, Eliza Martha, Kayo, Monica, Avrichir, Belquiz S, Sa, Antonio Reis, Camargo, Maria das Gracas Miquelutti, Napolitano, Isabel Cristina, Nery, Fabiano Gonçalves, Pinto, Jony Arrais, Bannwart, Silvia, Scemes, Silvia, Di Sarno, Elaine, Elkis, Helio
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Associated treatments
Behavior therapy. Cognitive therapy
Biological and medical sciences
Clozapine - therapeutic use
Cognitive therapy
Cognitive Therapy - methods
Comparative analysis
Drug Resistance
Follow-Up Studies
Humans
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopathology
Psychopathology. Psychiatry
Psychopharmacology
Quality of life
Schizophrenia
Schizophrenia - drug therapy
Schizophrenic Psychology
Studies
Treatments
Young Adult
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Beschreibung
Zusammenfassung:The use of cognitive-behavior therapy (CBT) in addition to antipsychotic regimen to treat persistent psychotic symptoms of schizophrenia is growing. The aim of this study was to compare the efficacy of CBT to a befriending (BF) control group in patients with schizophrenia who are refractory to clozapine. Twenty-one patients completed the 21-week trial. In comparison with the control group, the CBT group showed a significant improvement in the General Psychopathology and total score of the Positive and Negative Syndrome Scale, as well as an improvement of Quality of Life scale. The improvement in psychopathology persisted at 6-month follow-up assessment.
ISSN:0022-3018
1539-736X
DOI:10.1097/NMD.0b013e3181be7422