Human T lymphocyte migration towards the supernatants of human rhinovirus infected airway epithelial cells: influence of exercise and carbohydrate intake

Physical stress induces a marked redistribution of T lymphocytes that may be influenced by carbohydrate (CHO) availability, yet the effect of these on T lymphocyte migration towards infected tissue is unknown. Therefore, the aim of this study was to determine the effect of strenuous exercise and CHO...

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Veröffentlicht in:	Exercise immunology review 2009, Vol.15, p.127-144
Hauptverfasser:	Bishop, Nicolette C, Walker, Gary J, Gleeson, Michael, Wallace, Fiona A, Hewitt, Colin R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Athletes Blood Glucose - analysis Cells, Cultured - drug effects Cells, Cultured - immunology Cells, Cultured - secretion Cells, Cultured - virology Chemotaxis, Leukocyte - drug effects Cross-Over Studies Culture Media, Conditioned - pharmacology Dietary Carbohydrates - pharmacology Dietary Carbohydrates - therapeutic use Double-Blind Method Epithelial Cells - immunology Epithelial Cells - secretion Epithelial Cells - virology Exercise - physiology Exercise Test Glucose - pharmacology Glucose - therapeutic use Humans Hydrocortisone - blood Hydrocortisone - secretion Leukocyte Common Antigens - analysis Leukocyte Count Male Neuroimmunomodulation - drug effects Polysaccharides - pharmacology Polysaccharides - therapeutic use Rhinovirus - immunology Rhinovirus - physiology Running - physiology Stress, Physiological - immunology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - physiology
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Zusammenfassung:	Physical stress induces a marked redistribution of T lymphocytes that may be influenced by carbohydrate (CHO) availability, yet the effect of these on T lymphocyte migration towards infected tissue is unknown. Therefore, the aim of this study was to determine the effect of strenuous exercise and CHO ingestion on subsequent ex vivo lymphocyte migration towards the supernatants of a Human Rhinovirus (HRV)-infected bronchial epithelial cell line. In a randomised, cross-over, double-blind design, 7 trained males ran for 2 h at 60% VO2peak on two occasions with regular ingestion of either a 6.4% w/v glucose and maltodextrin solution (CHO trial) or placebo solution (PLA trial). Plasma glucose concentration was higher on CHO than PLA after exercise (P
ISSN:	1077-5552