The effect of high dose of cortisol on glucose-6-phosphatase and fructose-1,6-bisphosphatase activity, and glucose and fructose-2,6-bisphosphate concentration in carp tissues ( Cyprinus carpio L.)

The effect of a high dose of cortisol (200 mg kg −1 body mass) on juvenile carp was investigated. The activity of glucose-6-phosphatase in liver and of fructose-1,6-bisphosphatase in liver, kidney and muscle, the serum glucose and fructose-2,6-bisphosphate concentration as well as the serum concentr...

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Veröffentlicht in:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2003-07, Vol.135 (3), p.485-491
Hauptverfasser: Dziewulska-Szwajkowska, Daria, Łozińska-Gabska, Małgorzata, Adamowicz, Anna, Wojtaszek, Jan, Dzugaj, Andrzej
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Sprache:eng
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Zusammenfassung:The effect of a high dose of cortisol (200 mg kg −1 body mass) on juvenile carp was investigated. The activity of glucose-6-phosphatase in liver and of fructose-1,6-bisphosphatase in liver, kidney and muscle, the serum glucose and fructose-2,6-bisphosphate concentration as well as the serum concentration of the injected hormone were measured after 24, 72 and 216 h after intraperitoneal cortisol injection. The activities of fructose-1,6-bisphosphatase in liver and kidney and glucose-6-phosphatase in liver were elevated in comparison with the control, while the fructose-1,6-bisphosphatase activity in the muscle tissue was unchanged. After cortisol injection, the serum glucose level was nearly two times higher after 24 and 72 h and was still 50% higher after 216 h compared with controls. In contrast, the liver fructose-2,6-bisphosphate concentration was unchanged after 24 h. More than two times higher fructose-2,6-bisphosphate concentration was observed in liver after 72 h and it was still elevated after 216 h after the cortisol injection.
ISSN:1096-4959
1879-1107
DOI:10.1016/S1096-4959(03)00112-X