Reduced Drug Use and Hospitalization Rates in Patients Undergoing Hemodialysis Who Received Pharmaceutical Care: A 2-Year, Randomized, Controlled Study

Study Objective. To investigate the impact of a pharmaceutical care program managed by clinical pharmacists on drug use, drug costs, hospitalization rates, and drug‐related problems (DRPs) in ambulatory patients undergoing hemodialysis. Design. Prospective, randomized, controlled, longitudinal, 2‐year pilot study. Setting. Nonprofit university‐affiliated dialysis clinic. Patients. One hundred four patients older than 18 years with end‐stage renal disease (ESRD) who were undergoing a stable hemodialysis regimen for at least 3 months. Intervention. Patients were randomly assigned to receive either pharmaceutical care, consisting of one‐on‐one care, with in‐depth drug therapy reviews conducted by a clinical pharmacist (57 patients), or standard of care, consisting of brief drug therapy reviews conducted by a nurse (47 patients). Measurements and Main Results. Baseline data on demographic and clinical characteristics were collected. Mean numbers of concomitant drugs, drug costs, hospitalization rates, and lengths of stay were compared between the groups. In the pharmaceutical care group, DRPs were identified and recorded. Baseline age, length of time receiving hemodialysis, and etiology of ESRD were not significantly different between the groups. Mean number of concomitant drugs at baseline was similar between the groups. At the end of the 2‐year follow‐up, pharmaceutical care was associated with a significant decrease of 14% fewer drugs compared with standard of care, as documented during each drug therapy review (p