Adrenal cortical neoplasms in the pediatric population: A clinicopathologic and immunophenotypic analysis of 83 patients

Adrenal cortical neoplasms in pediatric patients (400 g), tumor size (>10.5 cm), vena cava invasion, capsular and/or vascular invasion, extension into periadrenal soft tissue, confluent necrosis, severe nuclear atypia, >15 mitotic figures/20 high power fields, and the presence of atypical mito...

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Veröffentlicht in:	The American journal of surgical pathology 2003-07, Vol.27 (7), p.867-881
Hauptverfasser:	WIENEKE, Jacqueline A, THOMPSON, Lester D. R, HEFFESS, Clara S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - metabolism Adenoma - pathology Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - pathology Adrenal Cortex Neoplasms - therapy Adrenalectomy Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma - metabolism Carcinoma - pathology Carcinoma - therapy Cell Count Cell Division Cell Nucleus - pathology Chemotherapy, Adjuvant Child Child, Preschool Endocrinopathies Female Humans Immunohistochemistry Immunophenotyping Male Malignant tumors Medical sciences
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Zusammenfassung:	Adrenal cortical neoplasms in pediatric patients (400 g), tumor size (>10.5 cm), vena cava invasion, capsular and/or vascular invasion, extension into periadrenal soft tissue, confluent necrosis, severe nuclear atypia, >15 mitotic figures/20 high power fields, and the presence of atypical mitotic figures. Vena cava invasion, necrosis, and increased mitotic activity (>15 mitotic figures/20 high power fields) independently suggest malignant clinical behavior in multivariate analysis.
ISSN:	0147-5185 1532-0979
DOI:	10.1097/00000478-200307000-00001