Synaptic plasticity in the subiculum

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term...

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Veröffentlicht in:Progress in neurobiology 2009-12, Vol.89 (4), p.334-342
Hauptverfasser: Behr, Joachim, Wozny, Christian, Fidzinski, Pawel, Schmitz, Dietmar
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container_title Progress in neurobiology
container_volume 89
creator Behr, Joachim
Wozny, Christian
Fidzinski, Pawel
Schmitz, Dietmar
description The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
doi_str_mv 10.1016/j.pneurobio.2009.09.002
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subjects Action Potentials - physiology
Animals
Cerebral Cortex - physiology
Hippocampus - cytology
Hippocampus - physiology
Humans
Learning - physiology
Models, Biological
Neural Pathways - anatomy & histology
Neural Pathways - physiology
Neuronal Plasticity - physiology
Pyramidal Cells - physiology
Signal Transduction - physiology
Synapses - physiology
title Synaptic plasticity in the subiculum
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