Synaptic plasticity in the subiculum

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term...

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Veröffentlicht in:	Progress in neurobiology 2009-12, Vol.89 (4), p.334-342
Hauptverfasser:	Behr, Joachim, Wozny, Christian, Fidzinski, Pawel, Schmitz, Dietmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Cerebral Cortex - physiology Hippocampus - cytology Hippocampus - physiology Humans Learning - physiology Models, Biological Neural Pathways - anatomy & histology Neural Pathways - physiology Neuronal Plasticity - physiology Pyramidal Cells - physiology Signal Transduction - physiology Synapses - physiology
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Beschreibung
Zusammenfassung:	The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
ISSN:	0301-0082 1873-5118
DOI:	10.1016/j.pneurobio.2009.09.002