Longitudinal analysis of the depressive effects of intravenous amiodarone on depolarization and repolarization: A case report

Summary Intravenous amiodarone (AMD) induces multiple antiarrhythmic effects via blocking of Na+ , Ca2+ , and IKr channels, and β receptors. A patient on chronic dialysis was administered AMD for nonsustained ventricular tachycardia after successful cardiopulmonary resuscitation. QT prolongation occ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cardiology 2009-12, Vol.54 (3), p.460-465
Hauptverfasser:	Yoshioka, Koichiro, MD, PhD, FJCC, Amino, Mari, MD, PhD, Matsuzaki, Atsushi, MD, Shima, Makiyoshi, MD, Fujii, Toshiharu, MD, Kanda, Shigetaka, MD, Deguchi, Yoshiaki, MD, Kodama, Itsuo, MD, PhD, Tanabe, Teruhisa, MD, PhD, FJCC
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiodarone - administration & dosage Amiodarone - blood Amiodarone - pharmacology Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacology Cardiopulmonary Resuscitation Cardiovascular Depolarization Depression, Chemical Electrocardiography, Ambulatory Humans Infusions, Intravenous Intravenous amiodarone Late potential Longitudinal Studies Male Middle Aged Repolarization Sodium Channel Blockers Tachycardia, Ventricular - physiopathology Tachycardia, Ventricular - therapy Time Factors Ventricular Function - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Intravenous amiodarone (AMD) induces multiple antiarrhythmic effects via blocking of Na+ , Ca2+ , and IKr channels, and β receptors. A patient on chronic dialysis was administered AMD for nonsustained ventricular tachycardia after successful cardiopulmonary resuscitation. QT prolongation occurred 5 h after AMD administration. AMD was withdrawn at 24 h because of prolonged QTc interval (716 ms), which persisted for a further 48 h (661 ms). Ventricular premature contraction (VPC) was significantly decreased at 7 h; however, VPC increased again after discontinuing AMD. Depolarization changes induced by the Na+ -channel blocking action of AMD were analyzed. There was increasing filtered QRS-duration and duration of low-amplitude signals at voltage
ISSN:	0914-5087 1876-4738
DOI:	10.1016/j.jjcc.2009.02.002