Gamma knife radiosurgery: a safe and effective salvage treatment for pituitary tumours not controlled despite conventional radiotherapy

ObjectiveWe report the use of ‘gamma knife’ (GK) radiosurgery in 25 patients with pituitary adenomas not cured despite conventional therapy, including external beam radiotherapy.Patients and methodsAll patients had previously received conventional radiotherapy for a mean of 11.8 years prior to recei...

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Veröffentlicht in:European journal of endocrinology 2009-12, Vol.161 (6), p.819-828
Hauptverfasser: Swords, F M, Monson, J P, Besser, G M, Chew, S L, Drake, W M, Grossman, A B, Plowman, P N
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Sprache:eng
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Zusammenfassung:ObjectiveWe report the use of ‘gamma knife’ (GK) radiosurgery in 25 patients with pituitary adenomas not cured despite conventional therapy, including external beam radiotherapy.Patients and methodsAll patients had previously received conventional radiotherapy for a mean of 11.8 years prior to receiving GK; 23 out of 25 had also undergone pituitary surgery on at least one occasion. Seventeen had hyperfunctioning adenomas that still required medical therapy without an adequate biochemical control – ten somatotroph adenomas, six corticotroph adenomas and one prolactinoma, while eight patients had non-functioning pituitary adenomas (NFPAs).ResultsFollowing GK, mean GH fell by 49% at 1 year in patients with somatotroph tumours. Serum IGF1 fell by 32% at 1 year and by 38% at 2 years. To date, 80% of the patients with acromegaly have achieved normalisation of IGF1, and 30% have also achieved a mean GH level of
ISSN:0804-4643
1479-683X
DOI:10.1530/EJE-09-0493