Practical application to time indicator of a novel white film formed by interaction of calcium salts with hydroxypropyl methylcellulose
We have found that a cast film forms a white film when an aqueous solution comprising hydroxypropyl methylcellulose (HPMC) and calcium salts such as calcium lactate pentahydrate (CLP) and calcium chloride (CaCl 2) is used. In contrast, the obtained white film was transformed into a transparent film...
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| Veröffentlicht in: | International journal of pharmaceutics 2010-01, Vol.383 (1), p.255-263 |
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| creator | Shiraishi, Sumihiro Sakata, Yukoh Yamaguchi, Hiroyuki |
| description | We have found that a cast film forms a white film when an aqueous solution comprising hydroxypropyl methylcellulose (HPMC) and calcium salts such as calcium lactate pentahydrate (CLP) and calcium chloride (CaCl
2) is used. In contrast, the obtained white film was transformed into a transparent film by the addition of purified water. The transformation time for the change from the white film to the transparent film was dependent on film thickness. The relationship between the transformation time and the film thickness was significantly correlated, and it was found that the white film could be adaptable as time indicator. The formation of a white film comprising HPMC and calcium salts was strongly dependent on temperature conditions. The objective of the present study is to investigate the mechanism of the formation of this white film because of the interaction between HPMC and calcium salts. The DSC and XRPD results indicate that the calcium salts affect the HPMC polymer phase in the cast film comprising HPMC and calcium salts. By carrying out attenuated total reflection Fourier transform infrared (ATR FT-IR) analysis, we found that the white film could be formed by the calcium salts affecting the region associated with the C–O–C, C–O, and CH
3 stretching of the HPMC polymer phase. |
| doi_str_mv | 10.1016/j.ijpharm.2009.09.024 |
| format | Article |
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2) is used. In contrast, the obtained white film was transformed into a transparent film by the addition of purified water. The transformation time for the change from the white film to the transparent film was dependent on film thickness. The relationship between the transformation time and the film thickness was significantly correlated, and it was found that the white film could be adaptable as time indicator. The formation of a white film comprising HPMC and calcium salts was strongly dependent on temperature conditions. The objective of the present study is to investigate the mechanism of the formation of this white film because of the interaction between HPMC and calcium salts. The DSC and XRPD results indicate that the calcium salts affect the HPMC polymer phase in the cast film comprising HPMC and calcium salts. By carrying out attenuated total reflection Fourier transform infrared (ATR FT-IR) analysis, we found that the white film could be formed by the calcium salts affecting the region associated with the C–O–C, C–O, and CH
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2) is used. In contrast, the obtained white film was transformed into a transparent film by the addition of purified water. The transformation time for the change from the white film to the transparent film was dependent on film thickness. The relationship between the transformation time and the film thickness was significantly correlated, and it was found that the white film could be adaptable as time indicator. The formation of a white film comprising HPMC and calcium salts was strongly dependent on temperature conditions. The objective of the present study is to investigate the mechanism of the formation of this white film because of the interaction between HPMC and calcium salts. The DSC and XRPD results indicate that the calcium salts affect the HPMC polymer phase in the cast film comprising HPMC and calcium salts. By carrying out attenuated total reflection Fourier transform infrared (ATR FT-IR) analysis, we found that the white film could be formed by the calcium salts affecting the region associated with the C–O–C, C–O, and CH
3 stretching of the HPMC polymer phase.</description><subject>Biological and medical sciences</subject><subject>Calcium Compounds - analysis</subject><subject>Calcium Compounds - chemistry</subject><subject>Calcium Compounds - metabolism</subject><subject>Calcium salts</subject><subject>Drug Interactions</subject><subject>General pharmacology</subject><subject>HPMC</subject><subject>Hypromellose Derivatives</subject><subject>Indicators and Reagents - analysis</subject><subject>Indicators and Reagents - chemistry</subject><subject>Indicators and Reagents - metabolism</subject><subject>Interaction</subject><subject>Medical sciences</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Methylcellulose - analysis</subject><subject>Methylcellulose - chemistry</subject><subject>Methylcellulose - metabolism</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Time Factors</subject><subject>Time indicator</subject><subject>White film</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-K1TAUxoMoznX0EZRsxFXv5G_TrkQGR4UBXeg6pGlCc0mbmqQz0yfwtSedW3QpnJAQft85h-8D4C1GR4xwfXU6utM8qDgeCULtcSvCnoEDbgStKBP1c3BAVDQVx4JegFcpnRBCNcH0JbjArahrgcQB_PkRlc5OKw_VPPvyyC5MMAeY3Wigm_rtK0QYLFRwCnfGw_vBZQOt8yO0IY6mh91ayGyeWhV1YUtD7ZYRJuVzgvcuD3BY-xge1jmGefVwNHlYvTbeLz4k8xq8sMon82a_L8Gvm88_r79Wt9-_fLv-dFtp2rJcEcLbtms4s33fYd2jpsNMqI5w1inFOm4ZVUIRy5Gi1rTlYNNyShXttW44vQQfzn3LGr8Xk7IcXdq2UJMJS5KCMsxx3aJC8jOpY0gpGivn6EYVV4mR3CKQJ7lHILcI5FaEFd27fcLSFW_-qXbPC_B-B1QqNtmoJu3SX44QIrAQpHAfz5wpftw5E2XSzkza9C4anWUf3H9WeQTuMKuR</recordid><startdate>20100104</startdate><enddate>20100104</enddate><creator>Shiraishi, Sumihiro</creator><creator>Sakata, Yukoh</creator><creator>Yamaguchi, Hiroyuki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100104</creationdate><title>Practical application to time indicator of a novel white film formed by interaction of calcium salts with hydroxypropyl methylcellulose</title><author>Shiraishi, Sumihiro ; Sakata, Yukoh ; Yamaguchi, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-22599b854fddb1cd08b147ab254baa4b5f43a7a2f50a3fe93fe1e9533a3dcc853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Calcium Compounds - analysis</topic><topic>Calcium Compounds - chemistry</topic><topic>Calcium Compounds - metabolism</topic><topic>Calcium salts</topic><topic>Drug Interactions</topic><topic>General pharmacology</topic><topic>HPMC</topic><topic>Hypromellose Derivatives</topic><topic>Indicators and Reagents - analysis</topic><topic>Indicators and Reagents - chemistry</topic><topic>Indicators and Reagents - metabolism</topic><topic>Interaction</topic><topic>Medical sciences</topic><topic>Methylcellulose - analogs & derivatives</topic><topic>Methylcellulose - analysis</topic><topic>Methylcellulose - chemistry</topic><topic>Methylcellulose - metabolism</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Time Factors</topic><topic>Time indicator</topic><topic>White film</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiraishi, Sumihiro</creatorcontrib><creatorcontrib>Sakata, Yukoh</creatorcontrib><creatorcontrib>Yamaguchi, Hiroyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiraishi, Sumihiro</au><au>Sakata, Yukoh</au><au>Yamaguchi, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Practical application to time indicator of a novel white film formed by interaction of calcium salts with hydroxypropyl methylcellulose</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2010-01-04</date><risdate>2010</risdate><volume>383</volume><issue>1</issue><spage>255</spage><epage>263</epage><pages>255-263</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>We have found that a cast film forms a white film when an aqueous solution comprising hydroxypropyl methylcellulose (HPMC) and calcium salts such as calcium lactate pentahydrate (CLP) and calcium chloride (CaCl
2) is used. In contrast, the obtained white film was transformed into a transparent film by the addition of purified water. The transformation time for the change from the white film to the transparent film was dependent on film thickness. The relationship between the transformation time and the film thickness was significantly correlated, and it was found that the white film could be adaptable as time indicator. The formation of a white film comprising HPMC and calcium salts was strongly dependent on temperature conditions. The objective of the present study is to investigate the mechanism of the formation of this white film because of the interaction between HPMC and calcium salts. The DSC and XRPD results indicate that the calcium salts affect the HPMC polymer phase in the cast film comprising HPMC and calcium salts. By carrying out attenuated total reflection Fourier transform infrared (ATR FT-IR) analysis, we found that the white film could be formed by the calcium salts affecting the region associated with the C–O–C, C–O, and CH
3 stretching of the HPMC polymer phase.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19766707</pmid><doi>10.1016/j.ijpharm.2009.09.024</doi><tpages>9</tpages></addata></record> |
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| subjects | Biological and medical sciences Calcium Compounds - analysis Calcium Compounds - chemistry Calcium Compounds - metabolism Calcium salts Drug Interactions General pharmacology HPMC Hypromellose Derivatives Indicators and Reagents - analysis Indicators and Reagents - chemistry Indicators and Reagents - metabolism Interaction Medical sciences Methylcellulose - analogs & derivatives Methylcellulose - analysis Methylcellulose - chemistry Methylcellulose - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Spectroscopy, Fourier Transform Infrared Time Factors Time indicator White film |
| title | Practical application to time indicator of a novel white film formed by interaction of calcium salts with hydroxypropyl methylcellulose |
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