The impact of age on the postprandial vascular response to a fish oil-enriched meal
Although chronic fish oil intervention had been shown to have a positive impact on vascular reactivity, very little is known about their acute effects during the postprandial phase. Our aim was to examine the impact of a fish oil-enriched test meal on postprandial vascular reactivity in healthy youn...
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| Veröffentlicht in: | British journal of nutrition 2009-11, Vol.102 (10), p.1414-1419 |
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| creator | Jackson, Kim G. Armah, Christopher K. Doman, Izzy James, Lewis Cheghani, Farah Minihane, Anne M. |
| description | Although chronic fish oil intervention had been shown to have a positive impact on vascular reactivity, very little is known about their acute effects during the postprandial phase. Our aim was to examine the impact of a fish oil-enriched test meal on postprandial vascular reactivity in healthy younger ( |
| doi_str_mv | 10.1017/S0007114509990742 |
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Our aim was to examine the impact of a fish oil-enriched test meal on postprandial vascular reactivity in healthy younger ( < 50 years) v. older ( ≥ 50 years) men. Vascular reactivity was measured at baseline (0 h), 2 and 4 h after the meal by laser Doppler iontophoresis and blood samples taken at 0 and 4 h for the measurement of plasma lipids, total nitrite, glucose and insulin. Acetylcholine- (ACh, endothelial-dependent vasodilator) and sodium nitroprusside (SNP, endothelial-independent vasodilator)-induced reactivities were greater at 4 h than at baseline or 2 h in the younger men (P < 0·04). These changes were not observed in the older men. Comparison of the male groups revealed significantly greater responses to ACh (P = 0·006) and SNP (P = 0·05) at 4 h in the younger compared with the older males. Postprandial NEFA concentrations were also greater at 4 h in the younger compared with the older men (P = 0·005), with no differences observed for any of the other analytes. Multiple regression analysis revealed age to be the most significant predictor of both ACh and SNP induced reactivity 4 h after the meal. In conclusion, the ingestion of a meal enriched in fish oil fatty acids was shown to improve postprandial vascular reactivity at 4 h in our younger men, with little benefit evident in our older men.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114509990742</identifier><identifier>PMID: 19563691</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>acetylcholine ; Acetylcholine - pharmacology ; Adult ; adults ; Age ; Aged ; Aging - physiology ; Animals ; Antioxidants ; Biological and medical sciences ; blood sampling ; blood vessels ; cyanides ; Diet ; Endothelium, Vascular - drug effects ; fatty acids ; Feeding. Feeding behavior ; Fish oil fatty acids ; Fish oils ; Fish Oils - pharmacology ; Fundamental and applied biological sciences. Psychology ; glucose ; Humans ; Ingestion ; insulin ; laser Doppler iontophoresis ; Lipids ; Male ; men ; Middle Aged ; nitrites ; Nitroprusside - pharmacology ; Nutrition ; Nutrition research ; Postprandial Period - physiology ; postprandial state ; sodium nitroprusside ; Vascular reactivity ; Vasodilation - drug effects ; Vasodilation - physiology ; Vasodilator Agents - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2009-11, Vol.102 (10), p.1414-1419</ispartof><rights>Copyright © The Authors 2009</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-7453441410f8b30ed0389b7fcf4ac74605f26d97180660cd8b5e2029e3ea6c503</citedby><cites>FETCH-LOGICAL-c537t-7453441410f8b30ed0389b7fcf4ac74605f26d97180660cd8b5e2029e3ea6c503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114509990742/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,781,785,27929,27930,55633</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22162116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19563691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, Kim G.</creatorcontrib><creatorcontrib>Armah, Christopher K.</creatorcontrib><creatorcontrib>Doman, Izzy</creatorcontrib><creatorcontrib>James, Lewis</creatorcontrib><creatorcontrib>Cheghani, Farah</creatorcontrib><creatorcontrib>Minihane, Anne M.</creatorcontrib><title>The impact of age on the postprandial vascular response to a fish oil-enriched meal</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Although chronic fish oil intervention had been shown to have a positive impact on vascular reactivity, very little is known about their acute effects during the postprandial phase. Our aim was to examine the impact of a fish oil-enriched test meal on postprandial vascular reactivity in healthy younger ( < 50 years) v. older ( ≥ 50 years) men. Vascular reactivity was measured at baseline (0 h), 2 and 4 h after the meal by laser Doppler iontophoresis and blood samples taken at 0 and 4 h for the measurement of plasma lipids, total nitrite, glucose and insulin. Acetylcholine- (ACh, endothelial-dependent vasodilator) and sodium nitroprusside (SNP, endothelial-independent vasodilator)-induced reactivities were greater at 4 h than at baseline or 2 h in the younger men (P < 0·04). These changes were not observed in the older men. Comparison of the male groups revealed significantly greater responses to ACh (P = 0·006) and SNP (P = 0·05) at 4 h in the younger compared with the older males. Postprandial NEFA concentrations were also greater at 4 h in the younger compared with the older men (P = 0·005), with no differences observed for any of the other analytes. Multiple regression analysis revealed age to be the most significant predictor of both ACh and SNP induced reactivity 4 h after the meal. In conclusion, the ingestion of a meal enriched in fish oil fatty acids was shown to improve postprandial vascular reactivity at 4 h in our younger men, with little benefit evident in our older men.</description><subject>acetylcholine</subject><subject>Acetylcholine - pharmacology</subject><subject>Adult</subject><subject>adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>blood sampling</subject><subject>blood vessels</subject><subject>cyanides</subject><subject>Diet</subject><subject>Endothelium, Vascular - drug effects</subject><subject>fatty acids</subject><subject>Feeding. Feeding behavior</subject><subject>Fish oil fatty acids</subject><subject>Fish oils</subject><subject>Fish Oils - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glucose</subject><subject>Humans</subject><subject>Ingestion</subject><subject>insulin</subject><subject>laser Doppler iontophoresis</subject><subject>Lipids</subject><subject>Male</subject><subject>men</subject><subject>Middle Aged</subject><subject>nitrites</subject><subject>Nitroprusside - pharmacology</subject><subject>Nutrition</subject><subject>Nutrition research</subject><subject>Postprandial Period - physiology</subject><subject>postprandial state</subject><subject>sodium nitroprusside</subject><subject>Vascular reactivity</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV-L1DAUxYso7uzqB_BFg7D6VM1N0qR9lKKrMOCf2QXfQpomM1nbppu0ot_e1Cm7oOhTSM7vnnDOzbIngF8BBvF6hzEWAKzAVVVhwci9bANMFDnhnNzPNoucL_pJdhrjdbqWgKuH2QlUBae8gk22uzwY5PpR6Ql5i9TeID-gKT2OPk5jUEPrVIe-q6jnTgUUTBz9EA2aPFLIunhA3nW5GYLTB9Oi3qjuUfbAqi6ax-t5ll29e3tZv8-3Hy8-1G-2uS6omHLBCsoYMMC2bCg2LaZl1QirLVNaMI4LS3hbCSgx51i3ZVMYgkllqFFcF5ieZS-PvmPwN7OJk-xd1Kbr1GD8HKWgDFI1ZCFf_JckQFORv8Hnf4DXfg5DSrEwJU0N8gTBEdLBxxiMlWNwvQo_JWC5LEb-tZg083Q1npvetHcT6yYScL4CqWrV2dS8dvGWIwQ4AVg-z4-ci5P5caur8E1yQUUh-cVnuRVfPm3rupZfE__syFvlpdqH5Hm1IzgFhpSY0sWRrnFU3wTX7s1d6H8H-gV0yLnZ</recordid><startdate>20091128</startdate><enddate>20091128</enddate><creator>Jackson, Kim G.</creator><creator>Armah, Christopher K.</creator><creator>Doman, Izzy</creator><creator>James, Lewis</creator><creator>Cheghani, Farah</creator><creator>Minihane, Anne M.</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20091128</creationdate><title>The impact of age on the postprandial vascular response to a fish oil-enriched meal</title><author>Jackson, Kim G. ; Armah, Christopher K. ; Doman, Izzy ; James, Lewis ; Cheghani, Farah ; Minihane, Anne M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-7453441410f8b30ed0389b7fcf4ac74605f26d97180660cd8b5e2029e3ea6c503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>acetylcholine</topic><topic>Acetylcholine - pharmacology</topic><topic>Adult</topic><topic>adults</topic><topic>Age</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Biological and medical sciences</topic><topic>blood sampling</topic><topic>blood vessels</topic><topic>cyanides</topic><topic>Diet</topic><topic>Endothelium, Vascular - drug effects</topic><topic>fatty acids</topic><topic>Feeding. Feeding behavior</topic><topic>Fish oil fatty acids</topic><topic>Fish oils</topic><topic>Fish Oils - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glucose</topic><topic>Humans</topic><topic>Ingestion</topic><topic>insulin</topic><topic>laser Doppler iontophoresis</topic><topic>Lipids</topic><topic>Male</topic><topic>men</topic><topic>Middle Aged</topic><topic>nitrites</topic><topic>Nitroprusside - pharmacology</topic><topic>Nutrition</topic><topic>Nutrition research</topic><topic>Postprandial Period - physiology</topic><topic>postprandial state</topic><topic>sodium nitroprusside</topic><topic>Vascular reactivity</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Kim G.</creatorcontrib><creatorcontrib>Armah, Christopher K.</creatorcontrib><creatorcontrib>Doman, Izzy</creatorcontrib><creatorcontrib>James, Lewis</creatorcontrib><creatorcontrib>Cheghani, Farah</creatorcontrib><creatorcontrib>Minihane, Anne M.</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Kim G.</au><au>Armah, Christopher K.</au><au>Doman, Izzy</au><au>James, Lewis</au><au>Cheghani, Farah</au><au>Minihane, Anne M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of age on the postprandial vascular response to a fish oil-enriched meal</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2009-11-28</date><risdate>2009</risdate><volume>102</volume><issue>10</issue><spage>1414</spage><epage>1419</epage><pages>1414-1419</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Although chronic fish oil intervention had been shown to have a positive impact on vascular reactivity, very little is known about their acute effects during the postprandial phase. Our aim was to examine the impact of a fish oil-enriched test meal on postprandial vascular reactivity in healthy younger ( < 50 years) v. older ( ≥ 50 years) men. Vascular reactivity was measured at baseline (0 h), 2 and 4 h after the meal by laser Doppler iontophoresis and blood samples taken at 0 and 4 h for the measurement of plasma lipids, total nitrite, glucose and insulin. Acetylcholine- (ACh, endothelial-dependent vasodilator) and sodium nitroprusside (SNP, endothelial-independent vasodilator)-induced reactivities were greater at 4 h than at baseline or 2 h in the younger men (P < 0·04). These changes were not observed in the older men. Comparison of the male groups revealed significantly greater responses to ACh (P = 0·006) and SNP (P = 0·05) at 4 h in the younger compared with the older males. Postprandial NEFA concentrations were also greater at 4 h in the younger compared with the older men (P = 0·005), with no differences observed for any of the other analytes. Multiple regression analysis revealed age to be the most significant predictor of both ACh and SNP induced reactivity 4 h after the meal. In conclusion, the ingestion of a meal enriched in fish oil fatty acids was shown to improve postprandial vascular reactivity at 4 h in our younger men, with little benefit evident in our older men.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>19563691</pmid><doi>10.1017/S0007114509990742</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acetylcholine Acetylcholine - pharmacology Adult adults Age Aged Aging - physiology Animals Antioxidants Biological and medical sciences blood sampling blood vessels cyanides Diet Endothelium, Vascular - drug effects fatty acids Feeding. Feeding behavior Fish oil fatty acids Fish oils Fish Oils - pharmacology Fundamental and applied biological sciences. Psychology glucose Humans Ingestion insulin laser Doppler iontophoresis Lipids Male men Middle Aged nitrites Nitroprusside - pharmacology Nutrition Nutrition research Postprandial Period - physiology postprandial state sodium nitroprusside Vascular reactivity Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | The impact of age on the postprandial vascular response to a fish oil-enriched meal |
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