Studies on the constituents of Adelostemma gracillimum

Studies on the constituents of Adelostemma gracillimum

The glycone portion of the glycoside of Adelostemma gracillimum Hook. f. (Asclepiadaceae) was investigated. Three known polyoxypregnane ester-type aglycones, penupogenin kidjoranine and gagamine, and one new compound named gracigenin were isolated and their structures were characterized on the basis...

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Veröffentlicht in:Planta medica 1992-04, Vol.58 (2), p.200-204
Hauptverfasser: Mu, Q. (Academia Sinica, Kunming (China). Inst. of Botany. Lab. of Phytochemistry), Shen, Y, Zhou, Q, Wang, S, Wu, B, Zheng, Q
Format: Artikel
Sprache:eng
Schlagworte:
8,14-seco-polyoxypregnane esterotype skeleton
Adelostemma gracillimum f
ASCLEPIADACEAE
Biological and medical sciences
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
ESTRUCTURA QUIMICA
General pharmacology
GLICOSIDOS
GLYCOSIDE
gracigenin
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PLANTAS MEDICINALES
PLANTE MEDICINALE
RACINE
RAICES
STRUCTURE CHIMIQUE
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Zusammenfassung:The glycone portion of the glycoside of Adelostemma gracillimum Hook. f. (Asclepiadaceae) was investigated. Three known polyoxypregnane ester-type aglycones, penupogenin kidjoranine and gagamine, and one new compound named gracigenin were isolated and their structures were characterized on the basis of spectroscopic evidence, and that of gagamine was determined by X-ray crystallography. It was found to possess an unprecedented 8,14-seco-polyoxypregnane ester-type skeleton, and it is the first compound with this C(21)-steroid type skeleton to be found in nature.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-961429