Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-protein block copolymers

Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-protein block copolymers

A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGD peptid...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (46), p.7104-7106
Hauptverfasser: Kim, Han-Nah, Lee, Jin, Kim, Hae-Yeong, Kim, Young-Rok
Format: Artikel
Sprache:eng
Schlagworte:
Acyltransferases - metabolism
Drug Carriers - chemical synthesis
Drug Delivery Systems - methods
Micelles
Oligopeptides - chemistry
Polyhydroxyalkanoates - chemistry
Polymers - chemical synthesis
Polymers - chemistry
Proteins - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGD peptide.
ISSN:1359-7345
1364-548X
DOI:10.1039/b912871a