Chronic Ethanol-Induced Glial Fibrillary Acidic Protein (GFAP) Immunoreactivity: An Immunocytochemical Observation in Various Regions of Adult Rat Brain

In the present study, the effects of chronic ethanol (ETOH) treatment on the glial fibrillary acidic protein (GFAP) immunoreactivity was investigated in adult rat brains. ETOH were administered as increasing concentrations of 2.4%-7.2% (v/v) gradually for 21 days. Immunocytochemistry revealed that c...

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Veröffentlicht in:	International journal of neuroscience 2009, Vol.119 (9), p.1303-1318
Hauptverfasser:	Dalçik, Hakki, Yardimoglu, Melda, Fi li z, Serdar, Gonca, Süheyla, Dalçik, Cannur, Erden, Beki r Faruk
Format:	Artikel
Sprache:	eng
Schlagworte:	adult rat brain Animals Astrocytes - physiology Brain Chemistry - drug effects Central Nervous System Depressants - blood Central Nervous System Depressants - pharmacology chronic ethanol treatment Ethanol - blood Ethanol - pharmacology glial fibrillary acidic protein (GFAP) Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry Male Rats Rats, Wistar
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Zusammenfassung:	In the present study, the effects of chronic ethanol (ETOH) treatment on the glial fibrillary acidic protein (GFAP) immunoreactivity was investigated in adult rat brains. ETOH were administered as increasing concentrations of 2.4%-7.2% (v/v) gradually for 21 days. Immunocytochemistry revealed that chronic-ETOH treatment increased synthesis of GFAP. The increase in the diameter and the number of GFAP (+) cells were statistically significant compared with the control group (p
ISSN:	0020-7454 1563-5279 1543-5245
DOI:	10.1080/00207450802333672