Effect of 5-Fluorouracil on Corneoscleral Wound Healing
5-Fluorouracil has been advocated as an adjunct to filtration in combined extracapsular cataract extraction, intraocular lens implantation, and trabeculectomy; however, it may exert an undesirable inhibitory effect on cataract wound healing. Accordingly, the effect of 5-fluorouracil on corneoscleral...
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Veröffentlicht in: | Journal of glaucoma 1994, Vol.3 (2), p.117-122 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 5-Fluorouracil has been advocated as an adjunct to filtration in combined extracapsular cataract extraction, intraocular lens implantation, and trabeculectomy; however, it may exert an undesirable inhibitory effect on cataract wound healing. Accordingly, the effect of 5-fluorouracil on corneoscleral wound healing was evaluated in an animal model. During the first 2 weeks following creation of full-thickness corneoscleral wounds, 40 rabbits were randomly assigned to receive either 10 subconjunctival injections of 5 mg 5-fluorouracil or normal saline. After sacrifice, 2, 4, 8, or 16 weeks postoperatively, the tensile strength of a 5-mm wound segment from each rabbit was measured with a tensiometer; histologic analysis was performed on untested portions of the wounds. 5-Fluorouracil was found to produce a trend toward decreased wound strength; however, this effect diminished over time. Histologic analysis was consistent with early inhibition of healing with resumption of healing following discontinuation of the drug. We conclude that 5-fluorouracil delays healing and development of tensile strength in rabbit corneoscleral wounds. |
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ISSN: | 1057-0829 1536-481X |
DOI: | 10.1097/00061198-199400320-00005 |