MicroRNAs Potentiate Neural Development

MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs that regulate mRNA expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any other tissue, where they are hypothesized to function in neural development. Recent reports describing the effects of specific miRNA...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2009-11, Vol.64 (3), p.303-309
Hauptverfasser:	Fineberg, Sarah K., Kosik, Kenneth S., Davidson, Beverly L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - embryology Brain - physiology Cell division Cerebral Cortex - embryology Cerebral Cortex - physiology Gene expression Gene Expression Regulation, Developmental - physiology Humans Mental Disorders - embryology Mental Disorders - genetics MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Models, Neurological MOLNEURO Neurogenesis - physiology Neurons - physiology Rhombencephalon - embryology Rhombencephalon - physiology RNA RNA polymerase Rodents Stem cells Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs that regulate mRNA expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any other tissue, where they are hypothesized to function in neural development. Recent reports describing the effects of specific miRNAs during development, and studies employing miRNA depletion as neural commitment proceeds in the embryo, support a requisite role for miRNAs in cell-fate decisions and provide clues to their function in other aspects of nervous system development.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/j.neuron.2009.10.020