Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols

Hard on cancer cells: Ferrocenyl quinone methides, potentially cytotoxic species, are formed by metabolic and chemical oxidation of ferrocenyl phenols (see scheme). These species display strong antiproliferative properties.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2009-11, Vol.48 (48), p.9124-9126
Hauptverfasser:	Hamels, Didier, Dansette, Patrick M., Hillard, Elizabeth A., Top, Siden, Vessières, Anne, Herson, Patrick, Jaouen, Gérard, Mansuy, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology antitumor agents Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects ferrocene Ferrous Compounds - chemistry Humans Indolequinones - chemical synthesis Indolequinones - metabolism Indolequinones - pharmacology metabolism Metallocenes Models, Molecular Molecular Structure Oxidation-Reduction Phenols - chemistry quinones Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Hard on cancer cells: Ferrocenyl quinone methides, potentially cytotoxic species, are formed by metabolic and chemical oxidation of ferrocenyl phenols (see scheme). These species display strong antiproliferative properties.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200903768