Silver-Mediated Direct Amination of Benzoxazoles: Tuning the Amino Group Source from Formamides to Parent Amines

Silver-Mediated Direct Amination of Benzoxazoles: Tuning the Amino Group Source from Formamides to Parent Amines

Going to the source: Formamides or parent amines were used as an amino group source for the silver‐mediated amination of benzoxazoles. Although reactions with formamides proceeded at high temperatures, the direct amination with amines took place under much milder conditions (see scheme). Optically a...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-11, Vol.48 (48), p.9127-9130
Hauptverfasser: Cho, Seung Hwan, Kim, Ji Young, Lee, S. Yunmi, Chang, Sukbok
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Amines - chemistry
benzoxazoles
Benzoxazoles - chemistry
CN coupling
formamides
Formamides - chemistry
Molecular Structure
silver
Silver - chemistry
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Zusammenfassung:Going to the source: Formamides or parent amines were used as an amino group source for the silver‐mediated amination of benzoxazoles. Although reactions with formamides proceeded at high temperatures, the direct amination with amines took place under much milder conditions (see scheme). Optically active amino groups could also be installed without racemization.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200903957