Detection by UPLC/ESI-TOF-MS of Alkaloids in Three Lycopodiaceae Species from French Polynesia and Their Anticholinesterase Activity

Three Lycopodiaceae species from French Polynesia, Lycopodium venustulum C. Gaudichaud, Lycopodiella cernua (C. Linnaeus) R. E. Pichi Sermolli and Lycopodium henryanum E. D. Brown were investigated for their alkaloidal composition by UHPLC/ESI-TOF-MS. Ten alkaloids were identified, with lycopodine a...

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Veröffentlicht in:	Natural product communications 2009-10, Vol.4 (10), p.1349-1352
Hauptverfasser:	Ho, Raimana, Marsousi, Niloufar, Eugster, Philippe, Bianchini, Jean-Pierre, Raharivelomanana, Phila
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Chromatography, Liquid - methods Lycopodiaceae - chemistry Molecular Structure Plant Leaves Polynesia Spectrometry, Mass, Electrospray Ionization - methods
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Zusammenfassung:	Three Lycopodiaceae species from French Polynesia, Lycopodium venustulum C. Gaudichaud, Lycopodiella cernua (C. Linnaeus) R. E. Pichi Sermolli and Lycopodium henryanum E. D. Brown were investigated for their alkaloidal composition by UHPLC/ESI-TOF-MS. Ten alkaloids were identified, with lycopodine and lycodoline being the main constituents in the three species. The acetylcholinesterase-inhibitory activities of the three species are probably due to the occurrence of huperzine A, huperzine B, huperzine E, huperzinine and lycopodine.
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X0900401007