Response to Vicriviroc in Treatment-Experienced Subjects, as Determined by an Enhanced-Sensitivity Coreceptor Tropism Assay: Reanalysis of AIDS Clinical Trials Group A5211

The enhanced-sensitivity Trofile assay (Monogram Biosciences) was used to retest coreceptor use at both study screening and study entry for 118 treatment-experienced subjects in AIDS Clinical Trials Group A5211 who had CCR5-tropic (R5) virus detected by the original Trofile assay at study screening....

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Veröffentlicht in:	The Journal of infectious diseases 2009-12, Vol.200 (11), p.1724-1728
Hauptverfasser:	Su, Zhaohui, Gulick, Roy M., Krambrink, Amy, Coakley, Eoin, Hughes, Michael D., Han, Dong, Flexner, Charles, Wilkin, Timothy J., Skolnik, Paul R., Greaves, Wayne L., Kuritzkes, Daniel R., Reeves, Jacqueline D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - drug therapy AIDS Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CCR5 Receptor Antagonists CD4 Lymphocyte Count Clinical trials Double-Blind Method Grants HIV HIV 1 HIV-1 - drug effects HIV-1 - genetics HIV-1 - metabolism HIV-1 - physiology HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Medical sciences Pharmacology. Drug treatments Piperazines - therapeutic use Pyrimidines - therapeutic use Receptors RNA RNA, Viral - metabolism Sensitivity and Specificity Statistics, Nonparametric Tropisms Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Tropism - drug effects Viral Tropism - physiology Virology Viruses
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Zusammenfassung:	The enhanced-sensitivity Trofile assay (Monogram Biosciences) was used to retest coreceptor use at both study screening and study entry for 118 treatment-experienced subjects in AIDS Clinical Trials Group A5211 who had CCR5-tropic (R5) virus detected by the original Trofile assay at study screening. Among 90 recipients of vicriviroc, a significantly (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/648090