A Rigid Helical Peptide Axle for a [2]Rotaxane Molecular Machine

A Rigid Helical Peptide Axle for a [2]Rotaxane Molecular Machine

Spinning around? A series of peptido[2]rotaxanes have been designed which contain a rigid helix as a significant part of their axle. One such rotaxane has been used to construct a reversible molecular device, in which, by virtue of the size of the inner cavity of the wheel relative to the outer diam...

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Veröffentlicht in:Angewandte Chemie International Edition 2009-11, Vol.48 (47), p.8986-8989
Hauptverfasser: Moretto, Alessandro, Menegazzo, Ileana, Crisma, Marco, Shotton, Elizabeth J., Nowell, Harriott, Mammi, Stefano, Toniolo, Claudio
Format: Artikel
Sprache:eng
Schlagworte:
Computer Simulation
Magnetic Resonance Spectroscopy
Molecular Conformation
molecular devices
NMR spectroscopy
peptides
Peptides - chemistry
rotaxanes
Rotaxanes - chemistry
structure elucidation
X-Ray Diffraction
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Beschreibung
Zusammenfassung:Spinning around? A series of peptido[2]rotaxanes have been designed which contain a rigid helix as a significant part of their axle. One such rotaxane has been used to construct a reversible molecular device, in which, by virtue of the size of the inner cavity of the wheel relative to the outer diameter of the peptide helix, a rotation of the wheel might occur concomitantly with its translation along the axle (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200904749