Correlation of the standardized uptake value in FDG-PET with the expression level of cell-cycle-related molecular biomarkers in resected non-small cell lung cancers

The aim of this study was to clarify the relationship between the maximum standardized uptake value (maxSUV) and the expression levels of cell-cycle-related molecular biomarkers. Thirty consecutive patients with non-small cell lung cancer (NSCLC) were enrolled in the study. Histologically, the tumor...

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Veröffentlicht in:	Annals of thoracic and cardiovascular surgery 2009-10, Vol.15 (5), p.304-310
Hauptverfasser:	Nakamura, Haruhiko, Hirata, Takeshi, Kitamura, Hajime, Nishikawa, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemistry Adenocarcinoma - diagnostic imaging Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Aged, 80 and over Biomarkers, Tumor - analysis Carcinoma, Non-Small-Cell Lung - chemistry Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Cell Cycle Proteins - analysis Cell Differentiation Cell Proliferation Female Fluorodeoxyglucose F18 Humans Immunohistochemistry Ki-67 Antigen - analysis Lung Neoplasms - chemistry Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Lung Neoplasms - surgery Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Positron-Emission Tomography Predictive Value of Tests Proliferating Cell Nuclear Antigen - analysis Radiopharmaceuticals Tumor Suppressor Protein p53 - analysis
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Zusammenfassung:	The aim of this study was to clarify the relationship between the maximum standardized uptake value (maxSUV) and the expression levels of cell-cycle-related molecular biomarkers. Thirty consecutive patients with non-small cell lung cancer (NSCLC) were enrolled in the study. Histologically, the tumors included 23 adenocarcinomas and 7 squamous cell carcinomas. Protein expressions of Ki-67, proliferating cell nuclear antigen (PCNA), and p53 were examined by immunohistochemistry. The maxSUV was higher in poorly differentiated NSCLCs than in well-differentiated and moderately differentiated tumors (p
ISSN:	2186-1005