Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients

Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in pat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurology 2003-06, Vol.60 (12), p.2006-2007
Hauptverfasser:	BASKIN, F, ROSENBERG, R. N, FANG, X, HYNAN, L. S, MOORE, C. B, WEINER, M, VEGA, G. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - blood Alzheimer Disease - drug therapy Amyloid beta-Peptides - blood Amyloid beta-Protein Precursor - blood Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Cholesterol - blood Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lovastatin - pharmacology Lovastatin - therapeutic use Medical sciences Neurology Niacin - pharmacology Niacin - therapeutic use Pravastatin - pharmacology Pravastatin - therapeutic use Protein Processing, Post-Translational - drug effects Simvastatin - pharmacology Simvastatin - therapeutic use Single-Blind Method
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.WNL.0000068029.56740.96